Antibodies that detect Progesterone Receptor can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Progesterone Receptor in Human, Mouse, Rat,...Antibodies that detect Progesterone Receptor can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Progesterone Receptor in Human, Mouse, Rat, Non-human primate and Feline samples. Our Progesterone Receptor...Antibodies that detect Progesterone Receptor can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Progesterone Receptor in Human, Mouse, Rat, Non-human primate and Feline samples. Our Progesterone Receptor monoclonal, polyclonal, recombinant monoclonal and cocktail antibodies are developed in Mouse, Rabbit and Rat. These antibodies have been verified by Relative expression, Cell treatment, IP-MS, Knockdown and Knockout to confirm specificity to Progesterone Receptor. Find the Progesterone Receptor antibody that fits your needs. Choose from 1 of 143 Progesterone Receptor antibodies, which have been...
Antibodies that detect Progesterone Receptor can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, ELISA and Immunoprecipitation. These antibodies target Progesterone Receptor in Human, Mouse, Rat, Non-human primate and Feline samples. Our Progesterone Receptor monoclonal, polyclonal, recombinant monoclonal and cocktail antibodies are developed in Mouse, Rabbit and Rat. These antibodies have been verified by Relative expression, Cell treatment, IP-MS, Knockdown and Knockout to confirm specificity to Progesterone Receptor. Find the Progesterone Receptor antibody that fits your needs. Choose from 1 of 143 Progesterone Receptor antibodies, which have been validated in experiments with 457 publications and 472 images featured in our data gallery.
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靶标信息
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
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